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Long-term exposure to diesel exhaust enhances antigen-induced eosinophilic inflammation and epithelial damage in the murine airway. Charcot-Leyden crystals (CLCs) are accepted as a morphologic hallmark of eosinophil-related disease in which there is active eosinophilic inflammation or proliferation. 5) Allergen skin testing is a highly sensitive and specific method of identifying environmental factors that elicit the IgE-mediated degranulation of mast cells and basophils that are the cornerstone of the subsequent eosinophilic inflammation characteristic of the allergic response. |
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