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ERE |
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The estrogen response element (ERE)--thymidine kinase-luciferase reporter gene (ERE-tk-Luc) consists of a consensus ERE with a minimal thymidine kinase promoter driving firefly luciferase activity. The estrogen binds to the ligand-binding domain, the binding domain changes shape, and it attaches to a docking site called an estrogen response element on certain genes. Modrenal does not bind to the receptors but inhibits the receptors from binding to estrogen response elements in DNA and stops estrogen- stimulated gene transcription. |
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