| Acronym | Definition |
|---|
| EPIC | Electronic Privacy Information Center |
| EPIC | Eclipse Plugin Central |
| EPIC | Electronic Publication(s) Information System |
| EPIC | European Prospective Investigation Into Cancer and Nutrition |
| EPIC | Explicitly Parallel Instruction Computing (HP/Intel) |
| EPIC | Elderly Pharmaceutical Insurance Coverage (NY state program) |
| EPIC | Etablissement Public à Caractère Industriel et Commercial (French) |
| EPIC | Education for Peace in Iraq Center |
| EPIC | Ethanol Promotion and Information Council |
| EPIC | El Paso Intelligence Center |
| EPIC | Edora Pool Ice Center (Fort Collins, Colorado) |
| EPIC | Environmental Protection Information Center |
| EPIC | European Photon Imaging Camera (X-ray Multi-Mirror space telescope) |
| EPIC | Evolving Personalized Information Construct (Sloan and Matt Thompson) |
| EPIC | End Poverty In California |
| EPIC | Erosion Productivity Impact Calculator (widely used computerized mechanistic crop model) |
| EPIC | Epidemiology and Prevention for Injury Control |
| EPIC | Embedded Platform for Industrial Computing |
| EPIC | Environment and Plastics Industry Council (Canada) |
| EPIC | Evidence Photographers International Council |
| EPIC | Engaging People in Cyberinfrastructure |
| EPIC | Educational Program Innovations Center |
| EPIC | Executive-Process/Interactive Control |
| EPIC | Electric Powered Interurban Commuter (DaimlerChrysler) |
| EPIC | Exemplary Public Interest Contribution (award) |
| EPIC | Electronic Picture(s) |
| EPIC | Environmental Photographic Interpretation Center |
| EPIC | Every Person Influences Children, Inc. |
| EPIC | Engineering, Procurement, Installation & Commissioning |
| EPIC | Environmental Prevention in Communities (Berkeley, California) |
| EPIC | Ex Police in Industry and Commerce |
| EPIC | Efficient Pyramid Image Coder |
| EPIC | ESOH (Environment, Safety, and Occupational Health) Program Integration Committee |
| EPIC | Effective Practice Incentive Community (Memphis, Tennessee) |
| EPIC | Edison Polymer Innovation Corporation |
| EPIC | European Public-Sector Information-Systems Conference |
| EPIC | Enhanced-Performance Implanted CMOS (Texas Instruments) |
| EPIC | Emory Public Interest Committee |
| EPIC | Experiential, Participatory, Image-rich and Connective |
| EPIC | European Privatization and Investment Corporation |
| EPIC | Enterprise Process Improvement Collaboration |
| EPIC | Exceptional People Impacting the Community |
| EPIC | Emergency Public Information Centre (SIngapore) |
| EPIC | Embedded Programmable Interrupt Controller |
| EPIC | Exchange Price Information Computer (UK) |
| EPIC | Emergency Preparedness and Injury Control (US DHS) |
| EPIC | Electronic Portable Information Collection |
| EPIC | Emergency Preparedness Integrated Communications |
| EPIC | Electronic Preassembly Integration on CATIA |
| EPIC | Engineering Process Improvement Center |
| EPIC | Experimental Image Compression |
| EPIC | Effective Practice Integration Council |
| EPIC | Engineer, Procure, Install, Commission (oilfield type of contract) |
| EPIC | Equatorial Pacific Information Collection |
| EPIC | Evaluation of Practice in Care |
| EPIC | Environmental Process Improvement Center (USAF) |
| EPIC | Engineering Physics Information Center (ORNL) |
| EPIC | Electrically Powered Indoor Wheelchairs |
| EPIC | Extended Programmable Input/Output Controller |
| EPIC | European Parallel Importers Coalition |
| EPIC | Emergency Performance Improvement Committee |
| EPIC | Emergency Preparedness Interaction Center |
| EPIC | Ethernet Port Interface Controller |
| EPIC | Engineering Planning, Integration, and Coordination |
| EPIC | Estes Park Improvement Contribution |
| EPIC | Exposure, Permeability, Impact, Criticality (software error effects) |
| EPIC | Evolutionary Process for the Integration of COTS-Based Systems |
| EPIC | Elite Para Insertion Corps (gaming clan) |
| EPIC | Earthquake, Preparedness and Incident Conference |
| EPIC | Electronic Procurement Information Console |
| EPIC | Estes Park Indoor Climbing |
| EPIC | Employees, Players, Inventory, Cash |
| EPIC | Elite Pros in Coalition (online gaming clan) |