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FGFR1

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AcronymDefinition
FGFR1Fibroblast Growth Factor Receptor 1


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Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4.
Pharmacodynamic assessments demonstrated substantial inhibition of IGF1R, SRC, Aurora B, and FGFR1 signaling in tumor samples from patients with small cell and non-small cell lung cancer.
Genomic amplification of the FGFR1 gene has also been detected in several types of cancer; in breast cancer this amplification correlates with reduced metastasis-free survival.
 
 
 
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