Regulation of cell survival and proliferation by the FOXO (Forkhead box, class O) subfamily of Forkhead transcription factors.
FoxOs at the crossroads of cellular metabolism, differentiation, and transformation.
What we have found is that these constituents can mimic insulin action on proteins known as FOXOs
," said Dr Rena.
and sirtuins in vascular growth, maintenance, and aging.
Interestingly, several longevity genes such as SIRT1, SIRT6, and FoxOs can clearly suppress NF-[kappa]B signaling and delay the aging process and extend lifespan (Tilstra et al.
In skeletal muscles, Akt stimulates glycogen synthesis via phosphorylation of GSK-3[beta] and inhibits protein degradation via phosphorylation of FoxOs (Brunet et al.
Sense and sensitivity: FOXO
and ROS in cancer development and treatment.
Seemingly, youth-extending drugs aimed at increasing the activity of the FOXO
and HSF-1 transcription factors may be useful for staving off Alzheimer's disease since the IGF pathway plays so many varied roles in the body.
Involvement of FOXO
transcription factors, TRAIL-FasL/Fas, and sirtuin proteins family in canine coronavirus type ll-induced apoptosis.
In cancer cell lines harboring PTEN mutations, NEI-induced nuclear entrapment of FOXO
, which is regulated by the PTEN/PI3K/Akt pathway, is directly linked to the induction of apoptosis.
2012) and forckhead transcription factor FOXO
(Wiegant et al.
elegans by inhibiting the FOXO
transcription factor DAF-16 (Lee et al.