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FOXO |
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The FOXO family of forkhead transcription factors is regulated by the PI3K/protein kinase B (PI3K/Akt) pathway and plays a key role in controlling cell cycle, apoptosis, oxidative stress, and immunomodulation (47). The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. |
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