FOXOFreedom of Xpression Online
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Regulation of cell survival and proliferation by the FOXO (Forkhead box, class O) subfamily of Forkhead transcription factors.
FoxOs at the crossroads of cellular metabolism, differentiation, and transformation.
What we have found is that these constituents can mimic insulin action on proteins known as FOXOs," said Dr Rena.
FOXOs and sirtuins in vascular growth, maintenance, and aging.
Interestingly, several longevity genes such as SIRT1, SIRT6, and FoxOs can clearly suppress NF-[kappa]B signaling and delay the aging process and extend lifespan (Tilstra et al.
In skeletal muscles, Akt stimulates glycogen synthesis via phosphorylation of GSK-3[beta] and inhibits protein degradation via phosphorylation of FoxOs (Brunet et al.
Seemingly, youth-extending drugs aimed at increasing the activity of the FOXO and HSF-1 transcription factors may be useful for staving off Alzheimer's disease since the IGF pathway plays so many varied roles in the body.
Involvement of FOXO transcription factors, TRAIL-FasL/Fas, and sirtuin proteins family in canine coronavirus type ll-induced apoptosis.
In cancer cell lines harboring PTEN mutations, NEI-induced nuclear entrapment of FOXO, which is regulated by the PTEN/PI3K/Akt pathway, is directly linked to the induction of apoptosis.