transcription factors: key regulators of cellular quality control.
The factor FOXO
is present in Mammals (Human also), and ecdysteroids (20E) can bind to oestrogenic receptors and cause similar effects to those induced by oestrogens (Jian et al.
regulates organ-specific phenotypic plasticity in Drosophila.
Denlinger, "Insulin signaling and FOXO
regulate the overwintering diapause of the mosquito Culex pipiens" Proceedings of the National Academy of Sciences of the United States of America, vol.
The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO
Researchers at Hawaii's Kuakini Medical Center have tracked a group of Japanese-American men since the 1960s, and discovered that they have a gene known as FOXO
, which doubles its possessor's chance of living to 100.
Stress-dependent regulation of FOXO
transcription factors by the SIRTL Science.
Phosphorylation of three highly conserved protein kinase B sites, corresponding to Thr24, Ser256, and Ser319 in human FOXO
1, suppresses transactivation and promotes nuclear exclusion of FOXO
proteins by multiple mechanisms (MacDougald et al.
If we can identify substances that restore FOXO
regulation in people with Type 2 diabetes, we might be able to use these to reduce the considerable burden of serious health problems associated with this diagnosis.
sup],, In mammals, the FOXO
protein sub-family includes FOXO
1, O3, O4, and O6, which are important transcription factors that function downstream of the PI3K/Akt signaling pathway.
An evolutionnary-conserved transcription factor, FOXO
, that both protects against aging and integrates signaling pathways involved in differentiation, cell survival and proteostasis is being examined using the nematode as a model for Huntington's disease (Christian Neri, Inserm U894 and Universite Paris Descartes, Paris, France).
The list of SIRT1 substrates is continuously increasing and includes numerous transcription factors for example: p53, members of the FOXO
family, hairy and enhancer of split 1 (HES 1), hairy/enhancer-of-split related with YRPW motif 2 (HEY2) , peroxisome proliferator - activated receptor gamma (PPAR g), chicken ovalbumin upstream promoter transcription factor (COUPTF)- interacting protein 2 (CTIP 2), p300, PGC-1 a (PPAR g coactivator), and nuclear factor kB (NFkB) (Michan and Sinclair, 2007; Pillarisetti, 2008; Haigis and Guarente, 2006; Yamamoto et al.