| Acronym | Definition |
|---|
| FIRST | Forum of Incident Response and Security Teams |
| FIRST | For Inspiration and Recognition of Science and Technology (youth organization founded by Dean Kamen) |
| FIRST | Fraunhofer-Institut für Rechnerarchitektur Und Softwaretechnik (German: Institute for Computer Systems and Software Technology) |
| FIRST | Facts on International Relations and Security Trends |
| FIRST | Faint Images of the Radio Sky At Twenty-Centimeters |
| FIRST | Foundry Industry Recycling Starts Today |
| FIRST | Foundation for Ichthyosis and Related Skin Types |
| FIRST | Far Infrared Space Telescope |
| FIRST | Federal Incident Response Support Team |
| FIRST | Forschungsinstitut für Rechnerarchitektur und Softwaretechnik (Germany) |
| FIRST | Fair and Immediate Resources for Students Today |
| FIRST | F/A-18E/F Integrated Readiness Support Teaming (US Navy) |
| FIRST | Financial Information Resource System (US Air Force) |
| FIRST | First Industrial Results of Semantic Technologies (Workshop) |
| FIRST | Flexographic Image Reproduction Specifications & Tolerances |
| FIRST | Fully Integrated Road Safety Technology |
| FIRST | Frontiers in Research: Space and Time (Eth Zurich, Swiss Federal Institute of Technology, Clean-Room Center) |
| FIRST | Florida Immediate Response Stress Team |
| FIRST | Fax Information Retrieval Support Technology |
| FIRST | Financial Incentive Rewards for Supervisors and Teachers (Prince George's County, Maryland) |
| FIRST | Foster Intervention/Retention Support Team |
| FIRST | Farm Family Income Recovery Support Team |
| FIRST | Financial Information Resources System |
| FIRST | Fabrication of Inflatable Reentry Structures for Test |
| FIRST | Future Interagency Range and Spaceport Technology Program (NASA) |
| FIRST | Flexible Infrared Search & Track |
| FIRST | Far-Infra-Red and Sub-Millimeter Telescope |
| FIRST | Florida Institute for Research, Science & Technology |
| FIRST | Future's Inventory Replenishment System Technology |
| FIRST | Forum of Incident Reporting & Security Team |
| FIRST | Fleet Integrated Readiness Support Team |
| FIRST | Financial Integrity Rating System in Texas |