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Most specimens feature a thick dermis that is marked by increased vascularity and prolific fibrous connective tissue. Desmoplasia involves the formation and proliferation of fibroblasts (cells that produce fibers and structural elements found in the extracellular matrix) and of fibrous connective tissue around the growing cancer. Histologically, the tumor consisted of astrocytic neuroglial cells that were surrounded by fibrous connective tissue and covered with normal nasal mucosa (figure 4). |
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