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Flt3

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AcronymDefinition
Flt3Fetal Liver Tyrosine Kinase 3


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Topics include maintenance of quiescent hematopoietic stem cells in the osteoblastic niche, NUP98 dysregulation in myeloid leukemogenesis, the role of thrombopoietin in mast cell differentiation, and the effect of FLT3 inhibition on normal hematopoietic progenitor cells.
Under the agreement, InVivoScribe Technologies will receive an exclusive license to use the patent worldwide, except in Japan, including the development, manufacture and sales of a reagent for detecting FLT3 gene mutations.
In pre-clinical testing, XL999 inhibited KDR, FGFR1, PDGFR-beta and FLT3 with high potency.
 
 
 
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