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pombe has no ortholog of XRCC1, and Pnk1 lacks the 17-kDa N-terminal domain present in hPNK, which contains a putative forkhead-associated domain (12). XRCC1 also binds PNK through the PNK forkhead-associated domain and stimulates the DNA kinase and DNA phosphatase activities at damaged DNA termini (13, 14). As mentioned, the N-terminal region is involved in binding DNA polymerase â, the C-terminal BRCT-II domain is responsible for binding to DNA ligase III and XRCC1 interacts with PARP through a central BRCT-I domain (8), and the linker region between the two BRCT domains which contains the CK2 phosphorylation sites interacts with the forkhead-associated domain of PNK (23). |
Forkhead-Associated |
forked out Forked River Assembly Area Forked River Mountain Coalition Forked River State Marina Forked Run State Park Forked tongue forked up forked up forked up forked up forked version forked version forker forker forker forker forker Forkerve forkful forkful forkful forkful forkful forkfuls forkfuls forkfuls forkfuls Forkhead box Forkhead Homologue in Rhabdomyosarcoma Forkhead, Drosophila, Homolog-Like Forkhead-Associated forkierforkiest Forkiness forking forking forking forking forking Forking Larkspur forking out forking out forking out forking out Forking proxy forking up forking up forking up forking up Forkless forklift forklift forklift Forklift Pockets Forklift truck Forklift truck forklift trucks forklift trucks forklifted forklifted forklifting | |||||
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