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Human monocytes and gingival fibroblasts release tumor necrosis factor-alpha, interleukin-1 alpha and interleukin-6 in response to particulate and soluble fractions of Prevotella melaninogenica and Fusobacterium nucleatum. In humans, this endotoxin can cause platelet aggregation) Other organisms that have been isolated in patients with Lemierre's syndrome include Fusobacterium nucleatum, Streptococcus spp, Peptostreptococcus spp, Bacteroides spp, Eikenella corrodens, and Gemella morbillorum. Coaggregation of Candida dubliniensis with Fusobacterium nucleatum. |
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