GADD34Growth Arrest and DNA Damage Protein 34
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ATF4, a crucial transcription factor, which is induced by PERK-mediation of phosphorylation of eIF2[alpha]; and activates pro-apoptotic factor CFIOP and GADD34 (Fian et al.
It is worth mentioning that CHOP induced GADD34 expression, which regulates restoration of protein synthesis via a negative feedback loop by dephosphorylation of eIF-2[alpha].
Mammalian GADD34, an apoptosis- and DNA damage-inducible gene.