GAP-43B-50/growth-associated protein-43
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Ephrin Inhibitory and Diffusible protein: A5 and A2; mammals attractant diffusible secreted to work have 8 ephrins and 13 proteins; ephrin A5: locally, as a gradient Eph receptors branching of axons to work long distance, or membrane bound GAP-43 Assist in critical Amplify environmental decisions signals Glial cells or glial Scaffold trophic Secretion of midline wedge support attractants and CAMS Laminin Trophic alone and Diffusible protein inhibitory when combined with Netrin-1 Netrins Midline attractant Diffusible protein; alone and inhibitory secreted when combined with laminin Neurotrophin family, Neuronal survival, Released from target i.
Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43.
GAP-43 and CAP-23 together induce up to 60 times as much nerve regrowth as either engenders alone, says coauthor J.
Two such proteins, MARCKS (myristoylated alanine-rich C-kinase substrate) and GAP-43 (growth-associated protein-43), amass in the spaces, or synapses, between brain cells and apparently affect the maturation and shape of the synapses, Routtenberg says.