GAP43Anti-Growth-Associated Protein 43
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In the presence of low-frequency ES, expression of the neurotrophin brain-derived neurotrophic factor, its high affinity receptor trkB, GAP43, and [beta]II-tubulin significantly increase shortly after femoral nerve injury [9-10].
acetylcholine, glutamate, and GABA) to natural activators such as diacylglycerol (DAG), phosphatidylserine (PS), arachidonic acid, and calcium, to PKC isozymes and then, to downstream substrates such as the mRNA stabilizing proteins (Hud, HuR), and, thereafter, to the synaptogenic proteins such as GAP43, BDNF, NGF, IGF, etc.
The poster, entitled "Optimized Dosing of Glial Growth Factor 2 in a Middle Cerebral Artery Occlusion Model Increases GAP43 Expression," reviewed data from study groups receiving differing doses of GGF2 to determine which dose was most effective in enhancing recovery of sensorimotor function after stroke.