| Acronym | Definition |
|---|
| GEM | Gateway to Educational Materials |
| GEM | Growth Enterprise Market |
| GEM | Global Entrepreneurship Monitor |
| GEM | Gender Empowerment Measure (UN) |
| GEM | Global Education Motivators |
| GEM | Grenoble Ecole de Management (French: Grenoble School of Management) |
| GEM | Graphics Environment Manager |
| GEM | Globally Executable MHP |
| GEM | German Equatorial Mount (telescope support structure) |
| GEM | General Equilibrium Model |
| GEM | Global Electric Motorcar |
| GEM | Global Emerging Market |
| GEM | Geriatric Evaluation & Management |
| GEM | Guidance Enhanced Missile |
| GEM | Generic Equipment Model |
| GEM | Global Energy Marketplace |
| GEM | Global Express Mail (USPS) |
| GEM | Generic Electronic Module (Ford) |
| GEM | Grupo de Educación Popular con Mujeres (Spanish: Education Group Popular with Women) |
| GEM | Ground Effect Machine |
| GEM | GPON Encapsulation Method |
| GEM | Guild of Experienced Motorists (now GEM Motoring Assist; UK) |
| GEM | The Group for Education in Museums |
| GEM | Gas Electron Multiplier (nuclear physics) |
| GEM | Graphite Epoxy Motor |
| GEM | Guideline Elements Model (XML-based guideline document model) |
| GEM | Groundwater Education in Michigan |
| GEM | Graduate Entry Medicine |
| GEM | Generalized Emulation of Microcircuits |
| GEM | Gulf Ecosystem Monitoring |
| GEM | Global Evangelization Movement |
| GEM | Genetically Engineered Microorganism |
| GEM | General Ecosystem Model |
| GEM | Galactic Emission Mapping |
| GEM | Goddard Earth Model |
| GEM | Ground Enhancement Material (Erico) |
| GEM | Generating Medicare Physician Quality Performance Measurement Results (Medicare; US DHHS) |
| GEM | Generalized Event Monitoring |
| GEM | Groupe d'Étude de la Main |
| GEM | GPS Embedded Module (Rockwell Collins) |
| GEM | Generation of Weather Elements for Multiple Applications |
| GEM | Government, Education and Major Accounts |
| GEM | General Elective Module |
| GEM | Graduate Engineering Management |
| GEM | Grupo Educativo Marin (Marin Educational Group) |
| GEM | Great Engineering Methodology |
| GEM | Generable Enigmatic Matrix (My-Otome anime and manga) |
| GEM | Global Engagement Manager (software in the Missile Defense Agency C2BMC element) |
| GEM | Ground Electronics Maintenance |
| GEM | Graphical Evaluation Module |
| GEM | Give Early Money |
| GEM | Gibbs Energy Minimisation |
| GEM | Government Electronic Mall (GSA) |
| GEM | Gifted Education in Mathematics |
| GEM | Global Enterprise Management of Storage |
| GEM | Global Education Multimedia |
| GEM | General Electric Metallized lamp (1904) |
| GEM | Gun Effectiveness Model |
| GEM | Georgia Enriches Minds |
| GEM | Generic Equipment Module |
| GEM | General Environmental Message |
| GEM | National Consortium for Graduate Engineering Degrees for Minorities |
| GEM | Ground Equipment Model |
| GEM | Gamma, Electron and Muon Detector |
| GEM | Guidance Evaluation Model |
| GEM | Global Electronics Modification |
| GEM | GIG (Global Information Grid) Enterprise Management (DoD Architectural Vision) |
| GEM | Global Execution Manager |
| GEM | General Executive Memo |
| GEM | Giant Antennal Mechanoreceptor |
| GEM | Goal Editor Module |
| GEM | Geriatric Emergency Management (Canada) |
| GEM | Gillett Evernham Motorsports (now Richard Petty Motosports) |
| GEM | Growing Equity Mortgage (loans) |
| GEM | Global Economic Monitor (World Bank) |
| GEM | Genetically Engineered Mouse |
| GEM | Global Environment Monitoring (EU) |
| GEM | Geriatric Emergency Medicine |
| GEM | Global Earthquake Model (est. 2006) |
| GEM | Greater Europe Mission (Monument, CO) |