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GIRK |
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For a recent example, a mutation in a strongly selective GIRK channel that introduced an ? GIRK channels are homomers or heteromers of four different subunits (GIRK1-4) that have been identified so far (14-18). Mutation of the residue analogous to Ala-336 of KCNQ1 in Shaker and G-protein activated GIRK K+ channels, and the bacterial Na+ channel NaChBac yielded channels with strongly open-state shifted open/close state equilibria (27-30). |
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