Ten studies (7 GLAL and 3 (CLAL) were limited to specific infection types (plague, 2 studies[7,17]; typhoid, 4 studies[16,20,26,30] salmonellosis, 1 study; meningococcal infections, 1 study; and urinary tract origin of infection, 2 studies[38,51].
Data on the proportion of non-Enterobacteriaceae among the gram-negative bacteremia isolates were available for 45 studies (25 GLAL studies and 20 CLAL studies).
The sensitivity limit for GLAL studies was usually in the range of 0.
For example, in the comparison of CLAL and GLAL in this analysis, the findings are not altered when small studies, studies that included documented infections, studies reporting per episode data, or all 3 of these categories of studies are excluded from the analysis.
The main finding of this meta-analysis is that the clinical utility of the LAL test would appear not to depend on whether a CLAL or GLAL version of the assay was employed.