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Increased GRP78 is a marker of intracellular and endoplasmic reticulum stress (ERS).
Membranes were subsequently blocked with 5% skim milk in Tris-buffered saline and Tween 20 (TBST) solution for 2h and were incubated with primary antibodies at 4[degrees]C overnight: RIPK3 (Cell Signaling, number 14401), RIPK1 (Cell Signaling, number 3493), GRP78 (Cell Signaling, number 3183), Phospho-mTOR (Ser2481) (Cell Signaling, number 2974), mTOR (Cell Signaling, number 2983), Calreticulin (Cell Signaling, number 12238), AKT (Cell Signaling, number 4685), and Phospho-AKT (Ser473) (Cell Signaling, number 4058).
In this study, myocardial GRP78 protein content showed a pattern of changes similar to that of changes in LC3-II protein content in different groups of animals, strongly suggesting an association between autophagy and oxidative stress.
GRP78 is part of a family of proteins called chaperones that help chains of amino acids in cells fold up in the correct way.
Targeting Heat Shock Proteins on Cancer Cells: Selection, Characterization, and Cell-Penetrating Properties of a Peptidic GRP78 Ligand.
GRP78 helps cells survive long enough for the UPR to kick in and is available in higher quantities in pancreatic cancer cells, which assists the cancer cells in evading cell death, allowing them to live and multiply.
This prompted the scientists to test whether GRP78 had an effect on the mammary stem cells.
CRIPTO/ GRP78 Signaling Maintains Fetal and Adult Mammary Stem Cells Ex Vivo"; Stem Cell Reports, 2014; 2 (4): 427 DOI: 10.
The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice.
miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo.
Cuando ocurre la acumulacion de proteinas anomalas en el RE, la GRP78 se disocia de cada receptor, lo que conduce a la activacion de la UPR (87).
The researchers went on to show that a protective "chaperone" protein called GRP78 positively regulated IP3R1 and that ER stress led to an impaired IP3R1-GRP78 interaction, which has also been observed in an animal model of HD.
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- Groznenskii Rabochii
- Groznyi Sheep
- GRP MOD
- GRP1-Associated Scaffold Protein