GRP78


Also found in: Medical.
AcronymDefinition
GRP78Glucose-Regulated Protein, 78-KD
References in periodicals archive ?
5,14) In a rat model of myocardial infarction, atorvastatin resulted in lower GRP78 and caspase-12 levels,15 and candesartan alleviated the ERS response after ureteric obstruction.
GRP78 is part of a family of proteins called chaperones that help chains of amino acids in cells fold up in the correct way.
Targeting Heat Shock Proteins on Cancer Cells: Selection, Characterization, and Cell-Penetrating Properties of a Peptidic GRP78 Ligand.
GRP78 helps cells survive long enough for the UPR to kick in and is available in higher quantities in pancreatic cancer cells, which assists the cancer cells in evading cell death, allowing them to live and multiply.
Up-regulation of GRP78 is associated with intrinsic and chemotherapy-induced resistance in many tumor types.
Thus, silencing GRP78 oncogene expression via the RNAi pathway may lead to cancer cell death.
Treatment of antioxidants, or pre-transfection of cells with GRP78 or CHOP siRNA reduced BFP-mediated apoptotic-related protein expression.
NKP-1339, a small molecule that down-regulates GRP78, has recently completed the dose-escalation portion of its Phase I clinical trial.
NKP-1339 is a first-in-class transferrin targeted small molecule that down-regulates GRP78, a key regulator of mis-folded protein processing and a tumor survival factor.
Using human prostate cancer cells in a laboratory culture, the team found that an antibody, called alpha2-macroglobulin (a2M), reacts with a cell surface receptor called GRP78 on the cancer cells to produce more PSA.
GRP78 is a central regulator of endoplasmic reticulum (ER) stress and has been used as a marker of ER stress.
Abstract No: 3590: Association of GRP78 polymorphisms with response and TTP in patients with mCRC treated with FOLFOX/BV or XELOX/BV.