GSTO and AS3MT genetic polymorphisms and differences in urinary arsenic concentrations among residents in Bangladesh.
Functional characterization of two variant human GSTO 1-1s (Ala140Asp and Thr217Asn).
As shown in Figure 2, all GSTs fall into three main branches that are comprised of eleven sub-branches, with GSTK solely in a clade, MAPEGs in a clade, and GSTO
, GSTZ, GSTR, GSTA, GSTP, GSTM and GSTT in a clade, respectively.
GSTO is capable of the reduction of monomethylarsenic(V) [MMA(V)] to monomethylarsenic(III) (Nemeti and Gregus 2004).
To address the need for genetic association studies aimed at testing the hypothesis of the existence of genetic determinants of interindividual variability in human arsenic metabolism, we used existing polymorphism catalogs for GSTO and PNP, produced a resequencing-derived catalog of polymorphisms in CYT19 (no such resequencing-based catalog was publicly available), and tested 23 polymorphic sites within these three genes in a population of arsenic-exposed subjects from the Yaqui Valley area of Sonora, Mexico, who had been phenotyped for the levels of urinary metabolites of arsenic.
We have previously published the resequencing results for GSTO and PNP (Yu et al.