Polymorphisms in NAT2, CYP2D2, CYP2C19, GSTP1
and their association with prostate cancer.
In light of the evidence that variants of GSTP1
and GSTM1 influence disease risk, we assessed the association of GST polymorphisms in young smoking and non-smoking South African Indian CAD patients.
MDxHealth, in collaboration with Johns Hopkins University, Cleveland Clinic, University of California Los Angeles, Lahey Clinic and Eastern Virginia Medical School, is currently conducting a multi-center clinical validation trial with its Prostate ConfirmMDx test featuring an expanded biomarker gene panel that includes GSTP1
and enhanced DNA extraction technology.
2], NO  Mitochondrial p53 dysfunction  NASH CYP2E1 [17,18] HBV, HCV RASSF1A, GSTP1
, CHRNA3, DOK1  HBV.
The GSTM1 and GSTP1
enzymes make the glutathione, while the SHMT and CTH enzymes provide the raw ingredients.
6] Human genes: KLK3, kallikrein-related peptidase 3; AR, androgen receptor; CYP17A1, cytochrome P450, family 17, subfamily A, polypeptide 1; CDKN2A, cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); CDH1, cadherin 1, type 1, E-cadherin (epithelial); CD44, CD44 molecule (Indian blood group); MGMT, O-6-methylguanine-DNA methyltransferase; RASSF1A, Ras association (RalGDS/AF-6) domain family member 1; ABCB1, ATP-binding cassette, sub-family B (MDR/TAP), member 1; APC, adenomatous polyposis coli; GSTP1
, glutathione S-transferase pi 1; BCL2, B-cell CLL/lymphoma 2; PTEN, phosphatase and tensin homolog.
We have been very impressed with the quality of methylated GSTP1
as a biomarker for prostate cancer," said Peter Klemm, Ph.
is built in blood lymphocytes and tissues such as prostate, lung, breast and brain.
The tumor suppressor genes included PTEN, CD44, WT1, GSTP1
, BRCA2, RB1, TP53, BRCA1, TP73, RARB, VHL, ESR1, PAX5A, CDKN2A, and PAX6.
6] (O-6-methylguanine-DNA methyltransferase) methylation in glioblastoma and GSTP1
(glutathione S-transferase pi 1) methylation in prostate cancers have well-worn studies and are of fered now in CLIA laboratories.
Cho, "Proteomic analysis of psoriatic skin tissue for identification of differentially expressed proteins: up-regulation of GSTP1
, SFN and PRDX2 in psoriatic skin," International Journal of Molecular Medicine, vol.
Genetic polymorphisms in PNP, GSTO1, GSTM1, GSTP1
, GSTT1, AS3MT, MTHFR, and CBS have been associated with the distribution of As metabolites in urine (Agusa et al.