A recent meta-analysis conducted in 2012 showed that GSTM1 and GSTT1
null polymorphisms were associated with a significantly increased risk of male infertility, whereas the GSTP1 Ile105Val polymorphism has a protective effect against the development of male infertility.
is found in lymphocytes and the liver, and is involved in the detoxification process of a variety of environmental chemicals, such as the ones used in polymer productions.
and GSTM1 polymorphisms and prostate cancer risk in Asians: A systematic review and meta-analysis.
The purpose of the present study was to evaluate whether GSTT1
and GSTM1 genes polymorphisms (presence or absence) can influence human susceptibility to leprosy and/or modulate the severity of this disease in a Southeast Brazilian population.
To detect GSTM1 and GSTT1
genotypes in the genomic DNA sample, multiplex polymerase chain reaction (PCR) was used.
Linkage and association studies of the relationship between endometriosis and genes encoding the detoxification enzymes GSTM1, GSTT1
Asn516Asn Paraquat GSTT1
Null allele Solvents GSTM1 Null allele Smoking GSTP1 GSTP1 * C haplotype Pesticides SLC6A3 51 A clade and 3' VNTR 9-repeats Paraquat, maneb SLC6A3 5' A clade and 3' VNTR 9-repeats Smoking MAO-B rsl799836 A>G Pesticides MnSOD rs4880 T>C p.
The purpose of the study was to investigate possible associations between glutathione S-transferases (GSTM1, GSTT1
, and GSTP1), superoxide dismutase (MnSOD Ala16Val), glutathione peroxidase (GPX1 Pro198Leu), catalase (CAT C262T) gene polymorphisms, and AML susceptibility in a Romanian population.
GSTM1 and GSTT1
null genotypes as possible heritable factors of rosacea," Photodermatology Photoimmunology and Photomedicine, vol.
Effects of occupation, life style and genetic polymorphism of CYP1A1, GSTM1, and GSTT1
on urinary 1-hydroxypyrene and 2-naphthol concentration.
Low grade intermediate prognosis (Table 4a) would be represented by intermediate functional limitation of the inflammatory pathway just involving one of the interleukins, total or intermediate functional limitation involving 2 detoxification pathways distinct from GSTM1 or GSTT1
and fast or intermediate pharmacogenetic profile at CYP2C9 and CYP2D6.
Genetic polymorphisms of GSTT1
, GSTM1, and NQO1 genes and diabetes mellitus risk in Chinese population.