We investigated the possible association between the GSTM1, GSTT1
, GSTP1 polymorphisms of GSTs genes and RA susceptibility in 100 patients (88 females and 12 males; mean age 44.
The present study conducted on 230 samples (115 each from pesticide exposed and control subjects), was aimed to evaluate the pesticides induced genotoxicity and to correlate genotoxicity with genetic polymorphism of CYP1A1, CYP3A5, PON1, GSTM1, GSTT1
, GSTP1 and NAT2 enzymes coding genes.
21] reported that the null genotype of GSTT1
was present in 64% of Chinese, 60% of Koreans, 28% of Caucasians and in 22% of African-Americans.
Polymorphisms of the genes encoding the GSTM1, GSTT1
and GSTP1 in Korean women: no association with endometriosis.
At present, there has been only 1 study published, with a small study population, describing a possible role of the GSTT1
deleted genotype and no role of the GSTM1 deleted genotype on the susceptibility for AD (18).
We selected 18 candidate genes related to As metabolism (PNP, GSTO1, GSTM1, GSTP1, GSTT1
, AS3MT, MTHFR, and CBS), oxidative stress (HMOX1, NOS3, SOD2, and CYBA), and inflammation/endothelial dysfunction (APOE, TNF, IL6, ICAM1, VCAM1, and S1PR1).
Dietary isothiocyanates, GSTM1, GSTT1
, NAT2 polymorphisms and bladder cancer risk.
In this study we describe the development, validation, and application of a cost-effective and rapid method for simultaneous genotyping of nine polymorphisms in five key enzymes involved in metabolism of xenobiotics: CYP1A2, GSTM1, GSTP1, GSTT1
, and NAT2.
Localization is seen in the mouse nuclei of hepatocytes and bile-duct epithelium, but a preferential nuclear localization of GSTT1
is not seen in the rat (Mainwaring et al.
When the participants were grouped by GST M1/T1 genotypes, the NAC effect was only significant among workers with null genotypes in both GSTM1 and GSTT1
(p = 0.
GSTM1 and GSTT1
polymorphism influences protection against induced oxidative DNA damage by quercetin and ascorbic acid in human lymphocytes in vitro.
Maternal smoking, GSTM1 and GSTT1
polymorphism and susceptibility to adverse pregnancy outcomes.