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Other a priori hypotheses were that PCB exposure would affect all-cause mortality, all cancer mortality, and, specifically, rectal, liver, biliary tract, and gallbladder cancer and non-Hodgkin lymphoma, for which other studies indicated increased risks (Brown 1987; Brown and Jones 1981; Rothman et al. When Gazdar's team tested 645 tumor samples representing 16 kinds of cancer, the gene's switch was methylated in most samples of lymphoma and stomach cancer, colorectal cancer, and gallbladder cancer. And while the vast majority of people with gallstones don't develop gallbladder cancer, between 75 percent and 90 percent of those who get gallbladder cancer have had gallstones. |
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