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Initially approved in 2001, Glivec, a single transduction inhibitor, is now available in over 80 countries worldwide and is indicated for the treatments of chronic myelocytic leukemia and gastrointestinal stromal tumor. Gastrointestinal stromal tumor, or GIST, is an unusual but highly lethal form of cancer. In this study, AMG 706 showed encouraging clinical activity in patients with advanced high-dose imatinib-resistant gastrointestinal stromal tumors (GIST). |
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