| Acronym | Definition |
|---|
| GSC | Graduate Student Council |
| GSC | Geological Survey of Canada (Department of Natural Resources Canada, Government of Canada) |
| GSC | Glenville State College |
| GSC | Guide Star Catalog (for Hubble Space Telescope) |
| GSC | Gold/Silver/Crystal (Pokémon video game series) |
| GSC | Golden Screen Cinemas |
| GSC | Glasgow Science Centre |
| GSC | Global Standards Collaboration |
| GSC | Genome Sequencing Center |
| GSC | Generalized Sidelobe Canceller |
| GSC | Germline Stem Cell |
| GSC | Girl Scout Cookies |
| GSC | Gunsmith Cats (anime) |
| GSC | Genetic Savings & Clone (USA) |
| GSC | Gas-Solid Chromatography |
| GSC | Ground Security Coordinator (airline industry) |
| GSC | GOOS Steering Committee |
| GSC | Generalized Selection Combining |
| GSC | Glassboro State College |
| GSC | Georgia Southern College |
| GSC | Gulf States Conference |
| GSC | General Steel Castings (railway cars) |
| GSC | Government Security Committee |
| GSC | General System Connect |
| GSC | Genetics Savings & Clone (UK) |
| GSC | Group Switching Centre |
| GSC | General System Characteristic |
| GSC | Georgeson Shareholder Communications |
| GSC | General Sciences Corp. (SAIC subsidiary) |
| GSC | Ground Station Control |
| GSC | Gameshark Central (website) |
| GSC | Guitar System Controller |
| GSC | General Staff Council |
| GSC | Generator Set Controller |
| GSC | Gridlock System Computer |
| GSC | Graphics System Connect (TAC-4) |
| GSC | Gunster Student Center (University of Scranton) |
| GSC | Ground Systems Controller |
| GSC | Gland Seal Condenser |
| GSC | Global Survey Cycle |
| GSC | Government Sponsored Corporation |
| GSC | Gouvernement Secret Cubain |
| GSC | Gross Sales Charge (finance) |
| GSC | Grooming Switch Card |
| GSC | Grid Spot Converter |
| GSC | Chief Gas Turbine System Technician (Naval Rating) |
| GSC | Group Study Course |
| GSC | Global Solutions Consulting, Inc (Century City, CA) |
| GSC | Global Security Client (software) |
| GSC | Gurango Software Corporation (Philippines) |
| GSC | Good Samaritan College (various locations) |
| GSC | Global Strike Command (US Air Force) |
| GSC | Gold Seal Certification (Canadian Construction Association) |
| GSC | Golden State Communications (California) |
| GSC | Glenwood Springs, Colorado |
| GSC | Generic Sildenafil Citrate (drug) |