| Acronym | Definition |
|---|
| GIS | Geographic Information System |
| GIS | Geographical Information System |
| GIS | Geographisches Informationssystem (German) |
| GIS | Geographic Information Services |
| GIS | Guaranteed Income Supplement (Canada) |
| GIS | Geographical Information Science |
| GIS | Geographical Information Services |
| GIS | Gentran Integration Suite (Sterling Commerce) |
| GIS | Gas-Insulated Switchgear |
| GIS | Genome Institute of Singapore |
| GIS | Global Information Society |
| GIS | General Information Services |
| GIS | Geospatial Information System |
| GIS | Gisborne, New Zealand (airport code) |
| GIS | Google Image Search |
| GIS | General Information Session |
| GIS | Geographic Information Solutions |
| GIS | Global Information Solutions |
| GIS | Gussoh Imagesystem |
| GIS | Geoscience Information Society |
| GIS | Gas Insulated Substation (electrical networks) |
| GIS | Geodata Interoperability Specification |
| GIS | Generalized Iterative Scaling |
| GIS | Government Information System |
| GIS | Garden International School (Malaysia) |
| GIS | Global Infrastructure Services (Computer Sciences Corporation) |
| GIS | Geographic Information Studies |
| GIS | Geographic Imaging Solutions |
| GIS | Ghana International School |
| GIS | Global Investment Systems |
| GIS | Geophysical Information System |
| GIS | Golisano Institute for Sustainability (Rochester Institute of Technology) |
| GIS | Global Indexing System |
| GIS | Group Information Session(s) |
| GIS | Graphics Information System |
| GIS | Gruppo d' Intervento Speciale (Italian Carabinieri Army Special Forces) |
| GIS | Georeferenced Information System |
| GIS | Global Inbound Service (international toll free service) |
| GIS | Green Iguana Society |
| GIS | Gastrointestinal Series |
| GIS | Groupe Interventional Speciale (Italian Counter Terrorism Unit) |
| GIS | General Investigative Section (Canada RCMP) |
| GIS | Geeky Internal Stuff (databases) |
| GIS | Geographical Imaging Software |
| GIS | Geosynchronous Meteorological Satellite |
| GIS | Gunbound International Server (gaming) |
| GIS | Group Interference Suppression |
| GIS | Gas Insulation System |
| GIS | Geographical Intelligent Survey |
| GIS | Group Index and Schedule |
| GIS | Global Insight Services (Congress WBN) |
| GIS | Greatness Is Simplicity |
| GIS | Goddard Information System |
| GIS | Guidelines Implementation Staff |