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GISSIGruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (Italian: Italian Group for the Study of the Survival of Myocardial Infarction)
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Most advice to take fish oil relies heavily on GISSI (Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico) and JELIS (Japan EPA Lipid Intervention Study) because they were so large.
Long-Term Effects of Intravenous Thrombolysis in Acute Myocardial Infarction: Final Report of the GISSI Study.
The GISSI has produced a series of large-scale clinical trials (GISSI 1 (http://www.
The larger GISSI Prevention Study randomized 11,324 Italians with recent myocardial infarctions to 850 mg of omega-3 fatty acids per day, 300 mg of vitamin E per day, neither, or both (31).
While not all studies have shown favorable results, the numbers of patients treated, the doses used, and the results of the DART, GISSI, and JELIS study are strong motivations for clinicians to recommend increased dietary fish intake and especially fish oil supplementation.
Omega-3 EPA and DHA reduce risk of sudden death up to 45%, and overall mortality of any cause by 20% in from any cause GISSI study; people need access to this information.
The largest, an Italian study called GISSI, randomly assigned more than 11,000 people who had recently suffered a heart attack to take either fish oil (850 mg of DHA plus EPA a day) or to see their doctor as usual.
Saccone C, Gissi C, Lanave C, Larizza A, Pesole G, Reyes A.
Last year brought the negative 11,324-patient Italian GISSI Prevention trial, followed by the nearly 10,000-patient Heart Outcomes Prevention Evaluation (HOPE) trial.
4 /PRNewswire/ -- Results from a new international study, the GISSI Heart Failure (GISSI-HF) study, showed that 1 g/d dose of omega-3 acid ethyl esters reduced all cause mortality and hospital admissions for cardiovascular reasons in patients with chronic heart failure.
El Khoury is based in New York and reports to Michele Gissi, Managing Director in Global Equity Derivatives.