The endogenous antibody should be classified as a specific HAAA [for example, human anti-rabbit antibody or human anti-mouse antibody (HAMA)].
If the interfering antibody shows activity against test antibodies from the same species, the interference may be classified as a specific HAAA if the interfering antibody shows a strong avidity for the suspected immunizing species compared with other species.
By adding the term specific to antibodies with clearly defined immunogens, the term HAMA or other HAAA could continue to be used to refer to a heterophile antibody recognized in mouse assays or other animal-specific assays.
That is to say, should specific human anti-animal (immunoglobulins) antibodies (HAAAs) be referred to as specific HAAAs rather than heterophile antibodies whenever possible?
Specific HAAAs also interfere with two-site immunoassays by bridging the capture and detection antibodies.