HAGMA

AcronymDefinition
HAGMAHigh Anion Gap Metabolic Acidosis (medical disorder)
References in periodicals archive ?
This mechanism is similar to that proposed to account for the excessive production of L-5-oxoproline in glutathione synthetase deficiency (3,21) and the resulting HAGMA seen in these subjects.
Furthermore, it is unlikely that the 5-oxoprolinuria was caused by HAGMA or abnormal liver function, with the presence of acetaminophen, a widely used analgesic, being merely a chance association.
It thus seems prudent to recommend that any subjects with HAGMA that cannot be adequately explained by increased lactate and/or 3-hydroxybutyrate concentrations should be investigated for the presence of 5-oxoproline in urine or plasma, and evidence of acetaminophen ingestion should be sought.