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HCV |
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In this study, we looked retrospectively for PARV4 and PARV5 in blood samples from a similar cohort of persons, many of whom were known to be infected with hepatitis C virus (HCV) (as determined by the presence of both HCV RNA and antibodies to HCV), and some of whom were intravenous drug users (IVDUs) (6). A recently completed Phase IIa monotherapy study demonstrated that celgosivir was well tolerated with some evidence of antiviral activity in treatment-naive chronic HCV patients. HCV undergoes a relatively simple replication cycle: cell entry; translation and cleavage of viral proteins; replication of viral RNA; and assembly and release of new viruses. |
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