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HDAC |
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As several of the identified genes may be activated or repressed through a pathway of histone deacetylase (HDAC) inhibition and specificity protein 1 activation, our data support a role of HDAC as an important molecular target of VPA action in vivo. and British colleagues added an HDAC inhibitor called suberoylanilide hydroxamic acid to the drinking water of young mice genetically engineered to make mutated huntingtin protein. His extensive pharmaceutical development and commercialization experience, especially in oncology, will be invaluable to Gloucester as our lead HDAC inhibitor, romidepsin, progresses from the clinic to the market. |
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