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HER1 |
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HER2 is part of a super-family of tyrosine kinase receptors which includes HER1, HER3 and HER4. The endocytosis is initiated by the clustering of clathrin, dynamin, and many other proteins triggered by a ligand binding to HER1 (27). Erlotinib blocks tumour cell growth by inhibiting the tyrosine kinase activity of the HER1 signalling pathway inside the cell. |
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