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HER2 |
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the HER2/CEP17 ratio may not be the best way to evaluate the HER2 status in all cases, and the absolute HER2 gene copy number may be the more important determinant for trastuzumab response for some patients Endocytosis of human epidermal growth factor receptor 2 (HER2), one of the HER family, simplifies the experimental setup because HER2 does not have a ligand binding step (36,37). Trastuzumab is a targeted therapy already used to treat advanced breast cancer with tumors that have excessive amounts of HER2 protein. |
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