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HER4 |
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HER2 is part of a super-family of tyrosine kinase receptors which includes HER1, HER3 and HER4. It belongs to a family of four transmembrane tyrosine kinase cell surface receptors which also includes HER1, HER3 and HER4. Our lead oral sheddase inhibitor, INCB7839, is in a Phase I/II dose-rising trial in refractory cancer patients with solid tumors such as breast, non-small cell lung, prostate, colorectal and head and neck cancers, all of which may be associated with excessive signaling of epidermal growth factor receptors including HER1, HER2, HER3 and HER4. |
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