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HERG |
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Third, the variety of cardiac function abnormalities we observed with both model tricyclic PAHs and weathered crude oil suggests several potential targets in the myocardium, which, in addition to HERG potassium channels, includes sarcoplasmic or plasma membrane calcium channels, as well as gap junctions. To test that theory, they first demonstrated that HERG lies within the expected region of chromosome 7. The collaboration will now continue through 2004 and include modeling of drug binding to the HERG potassium ion channel, as well as new evaluation of Pfizer compounds using Neurion's NP2 technology. |
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