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HGF/SF

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AcronymDefinition
HGF/SFMet-Hepatocyte Growth Factor-Scatter Factor


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ctn), the adaptor protein Gab 1, and the HGF/SF receptor Met.
Binding of HGF/SF to c-MET activates downstream signalling pathways such as Rho, focal adhesion kinase (FAK) and PI3K.
Data were also presented from a separate trial combining targeted therapies, in which AMG 102, a fully human monoclonal antibody that selectively targets HGF/SF (the only ligand for the c-Met receptor), was combined with bevacizumab or motesanib.
 
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