Moreover, the contribution of the local immunodeficiency in the pathogenicity of the Kaposi sarcoma is sustained by evidences of the presence of HHV8
factor, that sustain a direct relationship between the immune response and lymphatic drainage [15, 16].
Ademas, el HHV8
genera la produccion de interleucina 6 viral (IL-6), que bloquea la produccion de interferon alfa (IFN-[alfa]), el cual regula el ciclo celular normal [6,25]; de igual forma, se ha visto que la IL-6 viral es angiogenica, pues induce el factor de crecimiento endotelial vascular (Vascular Endothelial Growt Factor, VEGF) e induce la proliferacion de celulas B.
The lymphadenopathic form is the most common presentation (13) and may be the result of recent HHV8
infection with a rapid progression to malignancy (since the virus is tropic for lymph nodes during seroconversion).
However, tumour cells in PEL are co-infected by EBV and HHV8
and most cases do not express Ig light chains .
In the study, the team examined six female and two male organ recipients, and discovered that organ donors with HHV8
had infected three, and five others inherited HHV8
-related tumor cells.
While the protein encoded by the HHV8
gene can also bind to chemokines, it provokes a different response by cells.
The new data confirms not only that HHV8
is sexually transmitted, but also that it can cause Kaposi's sarcoma, the researchers said.
78) Although PEL, including its solitary variant and large B-cell lymphoma arising in HHV8
-associated multicentric Castleman disease, are both positive for HHV8
, the latter is typically negative for CD138 and EBV, (80) which distinguishes this type of aggressive B-cell lymphoma from traditional PBL.
genes encode numerous proteins that are homologous to cell-signalling and regulatory-pathway proteins, such as viral interleukin-6 (vIL-6) and D-type cyclin homologue (vcyc).
PCR was positive, He became pancytopenic and septic.
The detection of HHV8
in KS spindle cells is a useful tool in distinguishing KS from its mimics (figure 2).
A trio of recently published reports adds to the evidence against HHV8