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HMGB-1

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AcronymDefinition
HMGB-1High Mobility Group Box Chromosomal Protein 1


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The Company's current research and development portfolio includes HMGB-1, a pro-inflammatory substance identified as a mediator of TNF-associated tissue damage; development of small molecule and vagal nerve stimulation approaches to treat inflammation; and CTI-01, a proprietary anti-inflammatory drug candidate currently in Phase I clinical trials.
These products include its lead drug (an improved, controlled-release formulation of a drug currently approved for the treatment and prophylaxis of asthma), a cytoprotective drug to reduce trauma-related vascular and organ damage currently in Phase I clinical trials, and biologic products targeting HMGB-1, a novel pro-inflammatory cytokine to treat severe inflammatory diseases in partnership with MedImmune.
The Company's current research and development portfolio includes the following therapeutic targets: HMGB-1, a pro-inflammatory substance identified as a mediator of TNF-associated tissue damage; development of small molecule and vagal nerve stimulation approaches to treat inflammation; and CTI-01, a proprietary anti-inflammatory drug candidate currently in Phase I clinical trials.
 
 
 
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