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HNSCC |
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Our goal was to determine if EphB4 is aberrantly expressed in cases of HNSCC and to determine if there is a qualitative difference between the expression of EphB4 on primary and metastatic tumors and its expression on normal mucosa adjacent to primary tumors. Encouraging activity was reported in this open-label trial combining Tarceva with cisplatin and docetaxel in 37 evaluable patients with advanced HNSCC who had progressed following standard chemotherapy treatment. SLNBX potentially allows for the accurate staging of patients with HNSCC and NO necks while avoiding neck dissection. |
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