| Acronym | Definition |
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| HDC | Hill Descent Control (automobiles) | | HDC | High-Dose Chemotherapy | | HDC | Hard Disk Controller | | HDC | Housing Development Corporation (New York, NY) | | HDC | Health & Disability Commissioner (New Zealand) | | HDC | Histidine Decarboxylase | | HDC | Horticultural Development Council (UK) | | HDC | Home Detention Curfew (UK criminal system) | | HDC | Holder in Due Course (legal) | | HDC | Hydrodynamic Chromatography (analytical chemistry) | | HDC | Hydroelectric Design Center (US Army Corps of Engineers) | | HDC | Hard Drive Crash | | HDC | Helicopter Direction Center | | HDC | Hollandse Dagblad Combinatie | | HDC | Harbor Defense Command | | HDC | Hotel del Coronado | | HDC | Hardware Design Center | | HDC | Heartland Deaf Center, Inc. | | HDC | High Density Connector | | HDC | Harbor Defense Commander | | HDC | Hackers Dot Com | | HDC | Handle for Device Context (Microsoft Windows programming) | | HDC | Hasselblad Data Camera | | HDC | Habitability Design Center (US NASA) | | HDC | Hotel Development Council | | HDC | Hackers Digital Crime (German) | | HDC | Houston Dow Center | | HDC | Hybrid Driver Controller | | HDC | Helicopter Defense Command | | HDC | Helicopter Director Center | | HDC | Hijo del Cura (Spanish) | | HDC | Hawkins Data Center (California DOJ) | | HDC | Harmonie de Charlesbourg | | HDC | Helicopter Dynamic Component | | HDC | Harmonie de Coaticook |
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