| Acronym | Definition |
|---|
| HRS | Hours |
| HRS | Heart Rhythm Society |
| HRS | Health and Retirement Study |
| HRS | Hawaii Revised Statutes |
| HRS | House Rabbit Society |
| HRS | Hotel Reservation Service, Ltd |
| HRS | Hazard(ous) Ranking System |
| HRS | Harris Corp (stock symbol) |
| HRS | Health and Retirement Survey |
| HRS | Human Resources Services |
| HRS | Historic Resource Study (various locations) |
| HRS | Human Resources Specialist |
| HRS | Hepatorenal Syndrome |
| HRS | Hot Rolled Steel |
| HRS | High-Resolution Spectrograph |
| HRS | Human Resource Strategies |
| HRS | Household Responsibility System (China) |
| HRS | Health & Rehabilitative Services (State of Florida) |
| HRS | Heat Rejection System |
| HRS | Hrvatski Rukometni Savez (Croatian Handball Federation) |
| HRS | High-Resistivity Silicon |
| HRS | Housing Referral Service |
| HRS | Hair Replacement System |
| HRS | Hot Record Society (record label) |
| HRS | Hrvatski Ronilacki Savez (Croatian Scuba Diving Federation) |
| HRS | Human Resources Society (Medical Group Management Association) |
| HRS | High Resolution Separator (CERN) |
| HRS | Hazardous Ranking Score |
| HRS | High Road School |
| HRS | Hydrant Refuelling System |
| HRS | Harrisonburg Rescue Squad (Harrisonburg, Virginia) |
| HRS | Horizon Reference Set |
| HRS | High Rate Switch |
| HRS | Heading Reference Set |
| HRS | Hovering Rocket System |
| HRS | High Resolution Scenarios |
| HRS | Hrvatskog Ragbijaškog Saveza (Croatian Rugby Union) |
| HRS | Hybrid Routing and Scheduling |
| HRS | Hierarchical Resource Sharing |
| HRS | Heater Regeneration System |
| HRS | House Rent Subsidy |
| HRS | Hospital Readership Survey |
| HRS | Human Rights Society (various locations) |
| HRS | Holy Redeemer School (various locations) |
| HRS | Hydrogen Refueling Station (various organizations) |
| HRS | HTTP (Hypertext Transfer Protocol) Request Smuggling (computing) |
| HRS | High-Risk Strategy (various organizations) |
| HRS | Hrvatski Radioamaterski Savez (Croatian: Croatian Amateur Radio Association) |
| HRS | Hot Runner Systems NA Inc. (Windsor, Ontario, Canada) |