| Acronym | Definition |
|---|
| HPI | House Price Index (OFHEO) |
| HPI | Human Performance Improvement |
| HPI | History of Present Illness |
| HPI | Happy Planet Index |
| HPI | Health Policy Institute |
| HPI | Host Port Interface |
| HPI | Heifer Project International (international family self-reliance program) |
| HPI | High-Pressure Injection |
| HPI | Hogan Personality Inventory |
| HPI | Human Performance Institute |
| HPI | Holes per Inch (embroidery) |
| HPI | Hobby Products International |
| HPI | Hire Purchase Information |
| HPI | Hiroshima Peace Institute (Japan) |
| HPI | Hydrocarbon Process(ing) Industry |
| HPI | Health Promotion Institute |
| HPI | Hemera Photo-Object Image |
| HPI | High-Power Illuminator |
| HPI | High Potential Incident (safety) |
| HPI | High Probability of Intercept |
| HPI | Holcim Philippines, Inc. (cement manufacturer) |
| HPI | Health Provider Index (New Zealand) |
| HPI | Hazard Potential Index |
| HPI | Horn Plastics, Inc. |
| HPI | Hewlett Packard Invent |
| HPI | Hall Position Indicator (elevators) |
| HPI | Hydrographic Project Instructions |
| HPI | Horizontal Production Integration |
| HPI | Hermite Polynomial Interpolant |
| HPI | Huaneng Power International (China) |
| HPI | Health Promotion International (journal; International Union for Health Promotion and Education) |
| HPI | Hindu Press International (Hinduism Today) |
| HPI | Hasso Plattner Institute (Germany) |
| HPI | Health Plans, Inc. (Massachusetts) |