| Acronym | Definition |
|---|
| HPC | High Performance Computing |
| HPC | High Performance Concrete |
| HPC | High Performance Cluster |
| HPC | High Performance Computer |
| HPC | Hydrometeorological Prediction Center |
| HPC | Heterotrophic Plate Count |
| HPC | Human Performance Center |
| HPC | High Pressure Compressor |
| HPC | Hippocampus |
| HPC | Hydroxypropylcellulose |
| HPC | Health Professional Card (Germany) |
| HPC | Hematopoietic Progenitor Cells |
| HPC | Health Policy Center |
| HPC | Home and Personal Care |
| HPC | Health Professionals Council |
| HPC | Hereditary Prostate Cancer |
| HPC | Hewlett-Packard-Compaq |
| HPC | Handheld Personal Computer |
| HPC | Heat Pump Centre (Sweden) |
| HPC | Household and Personal Care |
| HPC | High Probability of Completion (telecommunications) |
| HPC | High Performance Coatings, Inc. |
| HPC | Halo PC (game) |
| HPC | High Performance Controller (IDNX) |
| HPC | Health Promotion Council of Southeastern Pennsylvania |
| HPC | Historical Preservation Committee |
| HPC | Hewlett Packard Consulting |
| HPC | Hydroprocessing Catalyst |
| HPC | Higher-Order Path Connection |
| HPC | Health Promotion Coordinator |
| HPC | Hertz Prestige Collection (Hertz Corporation) |
| HPC | Heavy Particle Cannon (gaming) |
| HPC | Hydrolyzed Protein Complex |
| HPC | High Power Command |
| HPC | Home Port Change |
| HPC | Halifax Parish Church (UK) |
| HPC | Hearing for Probable Cause |
| HPC | High-Power Characterization |
| HPC | High Pulse Command |
| HPC | Huron Port Cement (Pres Isle, Michigan) |
| HPC | Hydraulic Pump Controller |
| HPC | Hold Space Pressure Control |
| HPC | Hallmark Photographic Collection |
| HPC | HIP (History In your Pocket) Pocket Change (US Mint children's coin collecting website) |
| HPC | High Powered Inter-Ministerial Committee (India) |
| HPC | Headache & Pain Center (Leawood, KS) |
| HPC | High Pressure Cylinder |
| HPC | High-Productivity Computing |
| HPC | Historic Peace Church |
| HPC | High Pressure Cell |
| HPC | Healthpoint Capital, LLC (New York) |
| HPC | Honors Pre-Calculus (education) |
| HPC | Human-Powered Computing (Massachusetts Institute of Technology) |
| HPC | Hora Prevista de Chegada (Portuguese: Estimated Time of Arrival) |
| HPC | Hayan Petroleum Company (Syria) |
| HPC | Hospice Palliative Care (various locations) |
| HPC | Health Partnership Council (est. 1998; Rhode Island) |
| HPC | High Plains Community (various organizations) |
| HPC | Health Policy Committee (various organizations) |