| Acronym | Definition |
|---|
| HSD | Hybrid Synergy Drive (Toyota/Lexus) |
| HSD | Human Services Department |
| HSD | High Speed Data |
| HSD | High Speed Diesel |
| HSD | High School Diploma |
| HSD | Hillsboro School District (Hillsboro, OR) |
| HSD | Historical Society of Delaware |
| HSD | Hazelwood School District |
| HSD | Tukey's Honestly Significant Difference (aka the Tukey A Procedure; statistics; analysis) |
| HSD | History's Strongest Disciple (manga; Kenichi: The Mightiest Disciple) |
| HSD | High Speed Digital |
| HSD | Health Services Department |
| HSD | Hypoactive Sexual Desire |
| HSD | Horizontal Situation Display |
| HSD | Hardanger Sunnhordlandske Dampskipsselskap (Norway) |
| HSD | Hypertonic Saline Dextran |
| HSD | High Side Driver (electrical engineering) |
| HSD | Highway Safety Division (US and Canada) |
| HSD | Home Satellite Dish |
| HSD | Hartford Securities Distribution Company, Inc. |
| HSD | Hydrographic Surveys Division (NOAA) |
| HSD | Health and Safety Division |
| HSD | High School of Dundee (Scotland) |
| HSD | Human Systems Division |
| HSD | Home Delivery Service |
| HSD | Hicks Special Draught (beer) |
| HSD | High School Diplomats (student program) |
| HSD | Heat Sensing Device |
| HSD | High Strength Deformed (steel) |
| HSD | High Speed Deflectograph |
| HSD | Hardstyle Dance |
| HSD | 17-@beta Hydroxysteroid Dehydrogenase III Deficiency |
| HSD | Hamilton Standard Division |
| HSD | High Sulphur Diesel |
| HSD | Hot-Swap Drive |
| HSD | High Speed Drill |
| HSD | Hard Sphere Decoding |
| HSD | Head Supported Device(s) |
| HSD | High School Dublin |
| HSD | Hot Spot Detector |
| HSD | Health and Safety Document |
| HSD | Honestly Significant Difference technique (ITU-T) |
| HSD | Hot-Swappable Dimensions |
| HSD | Have Sweet Dreams (internet slang) |
| HSD | Home School Debate |
| HSD | Hyde School of Dance (UK) |
| HSD | Hot Surfer Dude |
| HSD | High Sierra Drifters (Road Flat, CA) |
| HSD | Health Service Delivery (various locations) |
| HSD | Health and Social Development (various organizations) |
| HSD | Harrisburg School District (Harrisburg, PA) |
| HSD | Highline School District (Washington) |
| HSD | Human Services Directory (various locations) |
| HSD | Hardware Software Development |