| Acronym | Definition |
|---|
| HDC | Hill Descent Control (automobiles) |
| HDC | Housing Development Corporation (New York, NY) |
| HDC | High-Dose Chemotherapy |
| HDC | Histidine Decarboxylase |
| HDC | Hard Disk Controller |
| HDC | Home Detention Curfew (UK criminal system) |
| HDC | Horticultural Development Council (UK) |
| HDC | Health & Disability Commissioner (New Zealand) |
| HDC | Holder in Due Course (legal) |
| HDC | Hard Drive Crash |
| HDC | Hydrodynamic Chromatography (analytical chemistry) |
| HDC | Hydroelectric Design Center (US Army Corps of Engineers) |
| HDC | Hotel del Coronado |
| HDC | Helicopter Direction Center |
| HDC | High Density Connector |
| HDC | Harbor Defense Command |
| HDC | Hollandse Dagblad Combinatie |
| HDC | Heartland Deaf Center, Inc. |
| HDC | Harbor Defense Commander |
| HDC | Hackers Dot Com |
| HDC | Hasselblad Data Camera |
| HDC | Habitability Design Center (US NASA) |
| HDC | Hardwoods Development Council (Pennsylvania Department of Agriculture; Harrisburg, PA) |
| HDC | Hardware Design Center |
| HDC | Handle for Device Context (Microsoft Windows programming) |
| HDC | Houston Dow Center |
| HDC | Hotel Development Council |
| HDC | Hackers Digital Crime (German) |
| HDC | Hybrid Driver Controller |
| HDC | Historical Data Collection (IBM) |
| HDC | Helicopter Defense Command |
| HDC | Helicopter Director Center |
| HDC | Hijo del Cura (Spanish) |
| HDC | Hawkins Data Center (California DOJ) |
| HDC | Harmonie de Charlesbourg |
| HDC | Helicopter Dynamic Component |
| HDC | Harmonie de Coaticook |
| HDC | Health Discovery Corporation (molecular diagnostics; Savannah, GA) |
| HDC | Hot Dog Cart |
| HDC | High Dependency Care (healthcare) |
| HDC | Hastings District Council (New Zealand) |
| HDC | Harborough District Council (UK) |
| HDC | Home Design Center (various locations) |
| HDC | Half Double Crochet |
| HDC | Heavy Duty Chassis (vehicles) |