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superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, [gamma]-glutamate cysteine ligase, glutathione S-transferase, NADPH quinone oxidoreductase, heme oxygenase 1) via a genetic response pathway that acquires transcriptional activation of the antioxidant response element (ARE) by the transcription factor nuclear regulatory factor 2 (Nrf2) (Li et al. Heme oxygenase (HO) is the rate-limiting enzyme that is involved in the degradation of heme to biliverdin, carbon monoxide, and iron. For example, in the short-term, HIF induces cytoprotective factors, such as heme oxygenase and adrenomedullin, and promotes changes in glucose metabolism that help conserve energy levels within cells when the oxygen supply is interrupted. |
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