| Acronym | Definition |
|---|
| HSS | Health, Safety and Security (US Department of Energy) |
| HSS | Humanities and Social Sciences |
| HSS | High Speed Steel |
| HSS | Hospital for Special Surgery (New York, NY, USA) |
| HSS | Home Subscriber Server (3GPP) |
| HSS | History of Science Society |
| HSS | Hughes Software Systems (subsidiary of Hughes Network Systems) |
| HSS | High-Speed Serial |
| HSS | Health Service Support |
| HSS | Hallervorden-Spatz Syndrome |
| HSS | Hollow Structural Section (AISC) |
| HSS | Hrvatska Seljacka Stranka (Croatian Peasants Party) |
| HSS | Hyper-Sonic Sound |
| HSS | Hallermann-Streiff Syndrome |
| HSS | High Speed Sealift |
| HSS | Hospital Shared Services |
| HSS | Home Service Store |
| HSS | Hulu Sungai Selatan |
| HSS | High Speed Switch (Sonet) |
| HSS | Humbucker-Single-Single (electric guitar pickup configuration) |
| HSS | Hrvatski Skijaški Savez (Croatian Ski Federation) |
| HSS | Heat Shrink Sleeve (coating industry) |
| HSS | Health and Support Services |
| HSS | Hunter Sensor Suite |
| HSS | Hollow Steel Section (steel) |
| HSS | Horizontal Stud Soderberg (aluminium production) |
| HSS | Higher Strength Steel |
| HSS | Health Screening System |
| HSS | Hydraulic Steel Structures (USACE) |
| HSS | Helicopter Support Ship |
| HSS | Heartland Senior Services |
| HSS | Health Support Service (Australia) |
| HSS | High Speed Stability |
| HSS | Hypothetical Stream Scheduler (digital TV) |
| HSS | Hrvatski Softball Savez (Croatian Softball Association) |
| HSS | Homer Simpson Syndrome (The Simpsons TV cartoon) |
| HSS | Host System Software (ITI) |
| HSS | High-Signal Select |
| HSS | Haemonetics Software Solutions (Edmonton, Alberta, Canada) |
| HSS | Hepatic Support System (liver system) |
| HSS | Helensvale State School (Gold Coast, Australia) |
| HSS | Historiae Societatis Socius (Fellow of the Historical Society) |
| HSS | Headquarters Support System |
| HSS | Hardware Support Specialist |
| HSS | High Spectral Sensor |
| HSS | Hot Spot Simulators |
| HSS | Highly Sensitive System |
| HSS | Horizontal Store Support |
| HSS | High Speed Solutions (various companies) |
| HSS | Hospital San Sebastian (Guatemala) |