| Acronym | Definition |
|---|
| HDS | Hitachi Data Systems |
| HDS | Harvard Divinity School |
| HDS | Honda Diagnostic System |
| HDS | Hydrodesulfurization (petroleum industry) |
| HDS | History Data Service |
| HDS | Héroes del Silencio (rock group) |
| HDS | Historical Diving Society |
| HDS | High Definition Systems |
| HDS | High Definition Sound |
| HDS | Holographic Data Storage |
| HDS | Hamilton Depression Scale |
| HDS | Hitachi Data Systems Solutions |
| HDS | Hazardous Devices School |
| HDS | Harry Dean Stanton (actor) |
| HDS | Historical Data Server (Cisco) |
| HDS | Harvard Design School |
| HDS | Highly Dispersible Silica |
| HDS | Hardware Design Specification |
| HDS | Hierarchic Dementia Scale |
| HDS | Hydrostatic Design Stress |
| HDS | Hybrid Dynamical System |
| HDS | His Divine Shadow (LEXX series TV) |
| HDS | Hachette Distribution Service (Lagardère SA) |
| HDS | Health and Diet Survey |
| HDS | Harbor Day School (Corona del Mar, CA) |
| HDS | Hardware Diagnostic Suite |
| HDS | Hard Disk Subsystem |
| HDS | Halon Distribution System |
| HDS | Hybrid Dynamic Simulator |
| HDS | Hierarchical Design System |
| HDS | Hybrid Decision Support |
| HDS | Human Designed Systems, Incorporated |
| HDS | High Day Service Hour |
| HDS | Heteroschedastic Database System |
| HDS | Home Digital Solutions (various companies) |
| HDS | Head of Defence Sales (UK Ministry of Defence; now Head of Defence Export Sales) |
| HDS | High Frequency Directional Finding Subsystem |
| HDS | High-Speed Digital Switch |
| HDS | Hartley Data Service, Inc. (Glenview, IL) |
| HDS | Housing Dining Services (various schools) |
| HDS | High Definition Scanning (3-dimensional laser scanning) |
| HDS | Herbal Dietary Supplement |
| HDS | Head of Democratic Services (UK) |
| HDS | Help Desk Support (information technology) |
| HDS | Health Delivery System (various organizations) |
| HDS | Half Day Sightseeing (tours) |