| Acronym | Definition |
|---|
| HSR | Hochschule für Technik Rapperswil (University of Applied Sciences Raperswil, Switzerland) |
| HSR | High Speed Rail |
| HSR | Health Services Research (journal) |
| HSR | High School Reunion |
| HSR | High Speed Research |
| HSR | High-Speed Research |
| HSR | Historic Sportscar Racing |
| HSR | Homestar Runner (cartoon) |
| HSR | Historic Structure Report (restoration) |
| HSR | Hidden Surface Removal (3D graphics) |
| HSR | Hamilton Street Railway |
| HSR | Homogeneously Staining (Chromosome) Region |
| HSR | Hampshire Swine Registry |
| HSR | Health Service Region |
| HSR | Human Speech Recognition |
| HSR | High School Redesign (various locations) |
| HSR | Hardcore Sports Radio (Sirius Satellite Radio Channel) |
| HSR | High School Rank |
| HSR | Hypersensitive Reaction |
| HSR | High-Speed Reader |
| HSR | Horseshoe Scout Reservation |
| HSR | Holley Stealth Ram (automotive engine part) |
| HSR | Hosur-Sarjapur Road (India residential area) |
| HSR | Holland Sleep Research |
| HSR | Houston Support Room |
| HSR | High Speed Rotor |
| HSR | Horizontal Spatial Resolution |
| HSR | High-Speed Relay |
| HSR | Hart-Scot-Rodino (US goverment's antitrust review of a merger or acquisition) |
| HSR | Health Sciences Review (journal) |
| HSR | Hardware Specification Review |
| HSR | Human Sciences Research, Inc. (McLean, VA) |
| HSR | Hyper-Surface of Revolution |
| HSR | Hallingdal Softgun Regiment |
| HSR | High Sensitivity Reception |
| HSR | Horizontal Scan Radius |
| HSR | High Speed Rewind |
| HSR | Haut Commissariat des Nations Unies pour les Réfugiés (United Nations High Commission for Refugees) |
| HSR | High Speed of Response |
| HSR | High School Red Cross |
| HSR | Hot Spare Requirement |
| HSR | Hospital Summary Report |
| HSR | High Sheet Resistance |
| HSR | Health and Safety Representative (Australia) |
| HSR | High Skin Refiner (cosmetic) |
| HSR | Human Subjects Review (various organizations) |