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When Ulloa and his colleagues began experimenting in lab dishes with human macrophages, a type of immune system cell, they discovered that the biochemical acetyl-choline put the brakes on the cells' production of the protein called high mobility group box 1 (HMBG1). 7,060,504, "Antagonists of HMG1 for Treating Inflammatory Conditions," involves methods of measuring the concentration of the protein High Mobility Group Box 1 (HMGB1) and comparing that concentration to a representative normal sample. Nasdaq: CRTX) today announced the achievement of a preclinical, proof-of-concept milestone in its High Mobility Group Box 1 (HMGB1) program with MedImmune, Inc. |
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