| Acronym | Definition |
|---|
| HS | High School |
| HS | Human Services |
| Hs | Significant wave height |
| HS | Home School |
| HS | Heat Shock (cells) |
| HS | High Speed |
| HS | Head Start |
| HS | Hot Spot |
| HS | Health and Safety |
| HS | Holy Spirit |
| HS | Headset |
| HS | Homeland Security |
| HS | Howard Stern (radio personality) |
| HS | Haus (German: House) |
| HS | Harmonized System |
| HS | Home Study (adoptions) |
| HS | Heat Sink (electronics) |
| HS | High Score |
| HS | High Standard |
| HS | Headshot (gaming) |
| HS | Homer Simpson (The Simpsons) |
| HS | Henschel (aircraft; Henschel Flugwerke AG; Germany) |
| HS | Herpes Simplex (skin disease) |
| HS | Hazardous Substance |
| HS | Outer Hebrides (postcode, United Kingdom) |
| HS | Home Station |
| HS | Hot Sauce |
| HS | Human Serum |
| HS | Hispano-Suiza (former car manufacturer) |
| HS | Heparan Sulfate |
| HS | Hydrogen Sulfide |
| HS | Horse Shoe |
| HS | Hassium (element 108) |
| HS | Higher Secondary |
| HS | Han Solo (Star Wars character) |
| HS | Helicopter Anti-Submarine Squadron (US Navy aviation unit designation used from 1951 to present) |
| HS | HyperSpace (game) |
| HS | Handshaking |
| HS | Heat Source |
| HS | HostServ (IRC) |
| HS | HelpServ (IRC) |
| HS | Head Shot (gaming) |
| HS | Hors Service (French: Out of Service) |
| HS | Hamstrings |
| HS | Hermetically Sealed |
| HS | Helter Skelter (Beatles song) |
| HS | Hamilton Sundstrand (company) |
| HS | Hot Standby (server connectivity) |
| HS | Half Step (Gunz the Duel video game) |
| HS | Hereditary Spherocytosis |
| HS | HyperStudio (multimedia authoring software) |
| HS | Heart Sounds |
| HS | Hand-Shake |
| HS | Hour of Sleep |
| HS | Hollywood Squares (TV game show) |
| HS | Half-Strength |
| HS | Homo Sapien |
| HS | Head & Shoulders (shampoo) |
| HS | Hollands Spoor (railway station; The Hague, Netherlands) |
| HS | Hebrew Scriptures (Old Testament) |
| HS | Hockey Skates |
| HS | Highway Service (Canada Post) |
| HS | Hand Stamp (philately; a cancel mark) |
| HS | Heat Sensor |
| HS | Health Services Technician |
| HS | Heel Strike (ergonomics) |
| HS | Hannah Spearritt (musician) |
| HS | Habitat Suitability (biology) |
| HS | Horn Strobe (fire alarms) |
| HS | Horizontal Scale |
| HS | Hand Switch (industrial control description) |
| HS | Hemorrhagic Septicemia (pasteurellosis) |
| HS | Hora Somni (Latin: At Bedtime or Just Before Sleep) |
| HS | Headquarters and Service |
| HS | Helioseismology |
| HS | Headline Sports (television) |
| HS | Hypothetical Syllogism |
| HS | Headphones Stereo (Sony Walkman) |
| HS | House Surgeon |
| HS | Hard Severe (rock climbing grade) |
| HS | Harmonized Standard |
| HS | Histiocyte Society |
| HS | Hypnotherapy Society |
| HS | Hollywood Scriptwriter (magazine) |
| HS | Hair Spring |
| HS | Hernial Sac |
| HS | Hic Situs (Latin: Here Is Laid) |
| HS | Haemophilia Society (UK) |
| HS | Horizon Sensor (aviation) |
| HS | Harlem Shake (dance) |
| HS | Heart Sense (game; University of Pennsylvania; Philadelphia, PA) |
| HS | Horizontal Slope |
| HS | Hrvatski Samokres (Croatian pistol brand) |
| HS | Hardness Surveillance |
| HS | Hydrofoil Ship |
| HS | Half Subtractor |
| HS | Harmonic Sampling (communication systems) |
| HS | Hawaiian Star (newspaper) |
| HS | Hamish Sinclair |
| HS | Hartford & Slocomb Railroad Company |
| HS | Highseekers (gaming clan) |
| HS | Hydraulic Fluid, Starboard, Ship Service |
| HS | He-3 Storage (helium) |
| HS | Hippocampus Sclerosis (neuropathology) Hippocampus Sclerosis (neuropathology) |
| HS | Hope Solo (soccer player) |