| Acronym | Definition |
|---|
| HOPE | Health Opportunities for People Everywhere |
| HOPE | Heart Outcomes Prevention Evaluation |
| HOPE | Hackers On Planet Earth |
| HOPE | History of Political Economy |
| HOPE | Hispanas Organized for Political Equality |
| HOPE | Helping Other People Excel |
| HOPE | Housing Opportunities for People Everywhere |
| HOPE | Helping Other People Eat |
| HOPE | HUMMER Owners Prepared for Emergencies (USA) |
| HOPE | Health Outcomes and Pharmacoeconomic (Research Centre) |
| HOPE | Helping Other People Everyday |
| HOPE | Healing of People Everywhere (Columbine High School fund) |
| HOPE | Helping Our People in Emergencies |
| HOPE | Harnessing Optimism and Potential Through Education |
| HOPE | Homeschool Organization of Parent Educators |
| HOPE | Honest, Orderly and Peaceful Election (Philippines) |
| HOPE | Homeless Outreach Projects and Evaluation |
| HOPE | Help Our People Excel |
| HOPE | Helping Out People Everywhere (Australia) |
| HOPE | Hillsborough Organization for Progress and Equality (Tampa, Florida) |
| HOPE | Hospitals for EurOPE (European Hospital and Healthcare Federation) |
| HOPE | H-2 Orbiting Plane (developmental Japanese space plane) |
| HOPE | Hydrogen Outreach Program for Education |
| HOPE | Hundreds of Original Projects for Employment (Austria) |
| HOPE | Human Organ Procurement and Exchange program |
| HOPE | Hearing Other Peoples Experience |
| HOPE | Halley Optical Probe Experiment |
| HOPE | Helping Obese People through Education |
| HOPE | Halt Overpopulation with Prevention and Education (animal foundation) |
| HOPE | Housing Our People Economically |
| HOPE | Harnessing the Omnipotent Power of the Electron (software tool) |
| HOPE | Heart Open Please Enter (Alcoholics Anonymous) |
| HOPE | Helping Open People's Eyes, Inc. (Texas; est. 1990) |
| HOPE | High-performance Open Portable Environment (Mobile Computing Systems) |
| HOPE | Humanitarian Organization for Palestinian Equality (student group; University of Michigan, Dearborn) |
| HOPE | Hillsboro Ohio Paranormal Encounters |
| HOPE | Hispanic Organization to Promote Education |
| HOPE | Highlights of Personal Experience |
| HOPE | Standing Committee for Hospitals in Europe |
| HOPE | Helping Other People Enthusiastically (outreach program; various locations) |
| HOPE | Healing Our Personal Environment |
| HOPE | Hispanic Organization of Postal Employees, Inc. |
| HOPE | Homes of Private Enterprise |
| HOPE | Heart of the Ozarks Parent Educators |
| HOPE | Hydrogen-Oxygen Primary Extraterrestrial Fuel Cell |
| HOPE | Health Organization to Preserve the Environment |
| HOPE | Health Options & Positive Energy Foundation |
| HOPE | Have Only Positive Expectations |
| HOPE | Hope and Opportunity for Postsecondary Education Act of 1997 |
| HOPE | Helping Our People Expand (student group) |
| HOPE | Heroin Overdose Prevention and Education |
| HOPE | Hold Onto Prayer Everyday |
| HOPE | He Offers Peace Eternally (Christianity) |
| HOPE | Huntsman Online Patient Education (Huntsman Cancer Institute; Salt Lake City, UT) |
| HOPE | Helping Our Planet Earth (various organizations) |
| HOPE | Honorable and Outstanding Police Enforcer (award; Manila, Philippines) |